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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Meiotic recombination checkpoint ： ウィキペディア英語版 Meiotic recombination checkpoint The meiotic recombination checkpoint monitors the meiotic recombination during meiosis, and blocks the entry into metaphase I if the recombination is not efficiently processed. Meiotic recombination contributes to the cells in three different ways. First, to achieve proper segregation, each pair of homologous chromosomes must be linked to each other to maintain a certain level of tension between them. Such tension is supposed to help the assembly of spindles and generally depends on meiotic recombination. Secondly, meiotic recombination increases the genetic diversity of gametes, making them readily adapt to new environment. Thirdly, meiotic recombination is a DNA repair process that removes damages from the DNA passed on to gametes. ==Overview== Generally speaking, the cell cycle regulation of meiosis is similar to that of mitosis. As in the mitotic cycle, these transitions are regulated by combinations of gene regulatory factors, cyclin-Cdk complex and the APC. The first major regulatory transition occurs in late G1, when the Start of meiotic cycle is activated by Ime1 instead of Cln3/Cdk1 in mitosis. The second major transition occurs at the entry into metaphase I. The main purpose of this step is to make sure that DNA replication has completed without error so that spindle pole bodies can separate. The event is triggered by the activation of M-Cdk in late prophase I. Then the spindle assembly checkpoint examines the attachment of microtubules at kinetochores and APCCdc20 can initiate the metaphase I. The special chromosome separation in meiosis, homologous chromosomes separation in meiosis I and chromatids separation in meiosis II, requires special tension between homologous chromatids and non-homologous chromatids for distinguishing microtubule attachment and it relies on the programmed DNA double strand break (DSB) and repair in prophase I. Therefore meiotic recombination checkpoint can be a kind of DNA damage response at specific time spot. On the other hand, the meiotic recombination checkpoint also makes sure that meiotic recombination does happen in every pair of homologs. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Meiotic recombination checkpoint」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.